Novel Ser/Thr Protein Phosphatases in Cell Death Regulation

Haipeng Sun, Yibin Wang

Abstract

Cell death is regulated by a myriad of intracellular molecular pathways, with many involving protein phosphorylation and dephosphorylation. In this review, we will focus on Ser/Thr phosphatases-mediated regulation in cell apoptosis as well as on their potential roles in cell necrosis. The emerging functional importance of Ser/Thr protein phosphatases in cell death regulation adds new dimension to the signaling mechanisms of cellular function, physiology, and diseases.

Footnotes

  • This work is supported in part by National Heart, Lung, and Blood Institute Grants HL-108186, HL-103205, HL-098954. H. Sun is supported by AHA post doc fellowship (Great Western Affiliate) and AHA Science Development Grant (National Research Center).

  • No conflicts of interest, financial or otherwise, are declared by the author(s).

  • Author contributions: H.S. and Y.W. conception and design of research; H.S. and Y.W. analyzed data; H.S. and Y.W. prepared figures; H.S. and Y.W. drafted the manuscript; H.S. and Y.W. edited and revised the manuscript; H.S. and Y.W. approved the final version of the manuscript.

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