Mechanisms of Protein Delivery to Melanosomes in Pigment Cells

Anand Sitaram, Michael S. Marks

Abstract

Vertebrate pigment cells in the eye and skin are useful models for cell types that use specialized endosomal trafficking pathways to partition cargo proteins to unique lysosome-related organelles such as melanosomes. This review describes current models of protein trafficking required for melanosome biogenesis in mammalian melanocytes.

Footnotes

  • This work was supported by National Institutes of Health Grants R01 EY-015625 and R01 AR-048155, and by National Institutes of Health Training Grants 2T32 HL-007971 and 5T32 GM-007229.

  • No conflicts of interest, financial or otherwise, are declared by the author(s).

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