An Inside View: VEGF Receptor Trafficking and Signaling

Michael Simons


Vascular endothelial growth factors (VEGF) and their receptors play a central role in the development of cardiovascular system and in vasculature-related processes in the adult organism. Given the critical role of this signaling cascade, intricate control systems have evolved to regulate its function. A new layer of added complexity has been the demonstration of the importance of endocytosis and intracellular trafficking of VEGF receptors in the regulation of VEGF signaling. In this review, we consider an evolving link between VEGF receptor endocytosis, trafficking, and signaling and their biological function.


  • This review was supported in part by National Heart, Lung, and Blood Institute Grants HL-53793 and HL-84619.

  • No conflicts of interest, financial or otherwise, are declared by the author(s).

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