cAMP and Mitochondria

Federica Valsecchi, Lavoisier S. Ramos-Espiritu, Jochen Buck, Lonny R. Levin, Giovanni Manfredi


Phosphorylation of mitochondrial proteins has emerged as a major regulatory mechanism for metabolic adaptation. cAMP signaling and PKA phosphorylation of mitochondrial proteins have just started to be investigated, and the presence of cAMP-generating enzymes and PKA inside mitochondria is still controversial. Here, we discuss the role of cAMP in regulating mitochondrial bioenergetics through protein phosphorylation and the evidence for soluble adenylyl cyclase as the source of cAMP inside mitochondria.


  • Funding was provided by National Institutes of Health Grants GM-088999 and Muscular Dystrophy Association, GM-62328, HD-059913, and NS-55255.

  • J. Buck and L. R. Levin own equity interest in CEP Biotech, which has licensed commercialization of a panel of monoclonal antibodies directed against sAC. All other authors declare no conflicts of interest, financial or otherwise.

  • Author contributions: F.V. and L.R.-E. prepared figures; F.V., L.R.-E., J.B., L.R.L., and G.M. drafted manuscript; F.V., L.R.-E., J.B., L.R.L., and G.M. edited and revised manuscript; F.V., L.R.-E., J.B., L.R.L., and G.M. approved final version of manuscript.

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