There is growing interest in understanding how dysregulated autophagy may contribute to pathogenesis of disease. Most frequently, disease states are associated with diminished autophagy, mostly attributed to genetic variation in autophagy genes and/or to dysfunctional posttranscriptional mechanisms. In human adipose tissue (AT), in obesity, expression of autophagy genes is upregulated and autophagy is likely activated, associating with adipose dysfunction. This review explores the emerging role of transcriptional mechanisms regulating AT autophagy in obesity.
We acknowledge support by grants from the Deutsche Forschungsge-meinschaft (DFG): SFB 1052/1: “Obesity mechanisms” (project B2 to A.R.), and the Israel Science Foundation (ISF 928/14 to A.R.). A.R is Chair of the Fraida Foundation in Diabetes Research.
No conflicts of interest, financial or otherwise, are declared by the author(s).
- ©2016 Int. Union Physiol. Sci./Am. Physiol. Soc.