Proteotoxicity refers to toxic stress caused by misfolded proteins of extrinsic or intrinsic origin and plays an integral role in the pathogenesis of cardiovascular diseases. Herein, we provide an overview of the current understanding of mechanisms underlying proteotoxicity and its contribution in the pathogenesis of amyloid cardiomyopathy.
This work is supported by grants from National Institute of Health (NIH), R01 HL-088533 (R. Liao), R01 HL-128135 (R. Liao and M. Jain), and K08 HL-107451 (M. Jain). V. Sapp is a recipient of NIH T32 Training (T32 GM-007752-37) awarded to Department of Pharmacology, UCSD.
No conflicts of interest, financial or otherwise, are declared by the author(s).
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