Eccentric muscle properties are not well characterized by the current paradigm of the molecular mechanism of contraction: the cross-bridge theory. Findings of force contributions by passive structural elements a decade ago paved the way for a new theory. Here, we present experimental evidence and theoretical support for the idea that the structural protein titin contributes to active force production, thereby explaining many of the unresolved properties of eccentric muscle contraction.
This research is funded by The Natural Sciences and Engineering Research Council (NSERC) of Canada, The Canadian Institutes of Health Research, The Canada Research Chair Programme, and The Killam Foundation.
No conflicts of interest, financial or otherwise, are declared by the author(s).
- ©2016 Int. Union Physiol. Sci./Am. Physiol. Soc.