Interstitial cells of mesenchymal origin form gap junctions with smooth muscle cells in visceral smooth muscles and provide important regulatory functions. In gastrointestinal (GI) muscles, there are two distinct classes of interstitial cells, c-Kit+ interstitial cells of Cajal and PDGFRα+ cells, that regulate motility patterns. Loss of these cells may contribute to symptoms in GI motility disorders.
The authors thank Peter Blair for the images in FIGURE 1, C AND D.
Work on ICC has been funded by Program Project Grants from the National Institute of Diabetes and Digestive and Kidney Diseases: P01 DK-41315 to K.M.S. and S.M.W., and R01 DK-57236 to S.M.W. and S.J.H. Work on PDGFRα+ cells has been funded by R01 DK-091336 to K.M.S. and S.M.W. Work on ICC and PDGFRα+ cells in situ has been funded by the 24th General Assembly of the Japanese Association of Medical Sciences to Y.K.
No conflicts of interest, financial or otherwise, are declared by the author(s).
- ©2016 Int. Union Physiol. Sci./Am. Physiol. Soc.