Most research on insulin resistance has focused on impaired signaling at the level of target tissues like skeletal muscle. Insulin delivery is also important and includes recruitment and perfusion of capillaries bearing insulin, but also the transit of insulin across the capillary endothelium. The mechanisms of this second stage (insulin transcytosis) and whether it contributes to insulin resistance remain uncertain.
This work was supported by Canadian Institutes of Health Research Grant MOP-130493 to A. Klip and W. Lee.
No conflicts of interest, financial or otherwise, are declared by the author(s).
- ©2016 Int. Union Physiol. Sci./Am. Physiol. Soc.