Fluid shear stress is an important environmental cue that governs vascular physiology and pathology, but the molecular mechanisms that mediate endothelial responses to flow are only partially understood. Gating of ion channels by flow is one mechanism that may underlie many of the known responses. Here, we review the literature on endothelial ion channels whose activity is modulated by flow with an eye toward identifying important questions for future research.
This work was supported by National Heart, Lung, and Blood Institute Grant PO1 HL-107235 to M.A.S.
No conflicts of interest, financial or otherwise, are declared by the author(s).
- ©2016 Int. Union Physiol. Sci./Am. Physiol. Soc.