Potassium homeostasis has a very high priority because of its importance for membrane potential. Although extracellular K+ is only 2% of total body K+, our physiology was evolutionarily tuned for a high-K+, low-Na+ diet. We review how multiple systems interface to accomplish fine K+ balance and the consequences for health and disease.
The authors are supported by National Institute of Diabetes and Digestive and Kidney Diseases Grant DK-083785 (to A. A. McDonough) and American Diabetes Association Basic Science Award 1-16-IBS-332 (to J. H. Youn).
No conflicts of interest, financial or otherwise, are declared by the author(s).
- ©2017 Int. Union Physiol. Sci./Am. Physiol. Soc.