The importance of endothelial cell (EC) metabolism and its regulatory role in the angiogenic behavior of ECs during vessel formation and in the function of different EC subtypes determined by different vascular beds has been recognized only in the last few years. Even more importantly, apart from a role of nitric oxide and reactive oxygen species in EC dysfunction, deregulations of EC metabolism in disease only recently received increasing attention. Although comprehensive metabolic characterization of ECs still needs further investigation, the concept of targeting EC metabolism to treat vascular disease is emerging. In this overview, we summarize EC-specific metabolic pathways, describe the current knowledge on their deregulation in vascular diseases, and give an outlook on how vascular endothelial metabolism can serve as a target to normalize deregulated endothelium.
↵* M. Dewerchin and P. Carmeliet contributed equally to this review.
L.B. is funded by a grant of the Leopoldina German National Academy of Science. L.-C.C. is funded by the Else Kröner Fresenius Stiftung and the Fritz Thyssen Stiftung. L.T. is supported by the Bettencourt Schueller Foundation. This work was supported by FWO-Vlaanderen, the Foundation Against Cancer, the Belgian Science Policy, long-term structural funding Methusalem funding by the Flemish Government, AXA Research Fund, an ERC Advanced Research Grant (EU-ERC269073 to P.C.), and the Foundation Leducq Transatlantic Artemis Network.
No conflicts of interest, financial or otherwise, are declared by the author(s).
- ©2017 Int. Union Physiol. Sci./Am. Physiol. Soc.