Our understanding of the fundamental biology and identification of efficacious therapeutic targets in aortic valve stenosis has lagged far behind the fields of atherosclerosis and heart failure. In this review, we highlight the most clinically relevant problems facing men and women with fibrocalcific aortic valve stenosis, discuss the fundamental biology underlying valve calcification and fibrosis, and identify key molecular points of intersection with sex hormone signaling.
The authors thank Drs. Sundeep Khosla and David G. Monroe for critical insights and feedback on the manuscript. This work was supported by NIH grants UH3-TR-000954 (J.D.M., M.E.S., H.V.S.), R01-HL-111121 (J.D.M.), and R01-AG-053832 (J.D.M.), and a Minnesota Biotechnology and Genomics Partnership Grant (J.D.M.).
No conflicts of interest, financial or otherwise, are declared by the author(s).
- Copyright © 2017 Int. Union Physiol. Sci./Am. Physiol. Soc.