Obese individuals frequently develop hypertension, which is for an important part attributable to renin-angiotensin-aldosterone system (RAAS) overactivity. This review summarizes preclinical and clinical evidence on the involvement of dysfunctional adipose tissue in RAAS activation and on the renal, central, and vascular mechanisms linking RAAS components to obesity-associated hypertension.
No conflicts of interest, financial or otherwise, are declared by the author(s).
- Copyright © 2017 Int. Union Physiol. Sci./Am. Physiol. Soc.