Interferon regulatory factors (IRFs) are evolutionarily conserved proteins expressed not only in immune cells but also in other tissues and organs outside the immune system. In this review, we discuss mechanisms responsible for IRF-mediated innate immune responses and the function and mechanism of IRFs in cardiometabolic diseases. We focus on the role of IRFs in innate immunity and cardiometabolic homeostasis, and highlight reprogrammed IRF signaling.
This work was supported by grants from the National Science Fund for Distinguished Young Scholars (no. 81425005), the Key Project of the National Natural Science Foundation (no. 81330005), the National Natural Science Foundation of China (nos. 81370209, 81370365, 81270184, and 31371481), the National Science and Technology Support Project (no. 2013YQ030923-05, 2014BAI02B01, 2015BAI08B01), and the China Postdoctoral Science Foundation funded project (no. 2016M602368).
No conflicts of interest, financial or otherwise, are declared by the author(s).
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