The utero-placental circulation links the maternal and fetal circulations during pregnancy, ensuring adequate gas and nutrient exchange, and consequently fetal growth. However, our understanding of this circulatory system remains incomplete. Here, we discuss how the utero-placental circulation is established, how it changes dynamically during pregnancy, and how this may impact on pregnancy success, highlighting how we may address knowledge gaps through advances in imaging and computational modeling approaches.
The authors acknowledge funding support from the Royal Society of New Zealand Marsden Fund (A.R.C. and J.L.J.) and Royal Society of New Zealand Rutherford Discovery Fellowship (A.R.C.).
- Copyright © 2017 Int. Union Physiol. Sci./Am. Physiol. Soc.