TABLE 1.

Developmental and physiological roles of HIF-1 as established by analysis of HIF-1α-null mice and cell lines

Role(s)References
HIF, hypoxia-inducible factor
Development
    Cardiovascular development. embryonic survival7, 26, 39, 60
    Chondrogenesis/skeletal development62
    Adipogenesis88
    B lymphocyte development38
    Mammary gland development64
Physiology
    Angiogenesis5, 34, 60
    Hypoxia-induced glycolysis26, 65
    Hypoxia-induced apoptosis5
    Hypoxia-induced erythropoiesis86
    Hypoxia-induced pulmonary vascular remodeling71, 86
    Carotid body sensing of arterial Po235
    Myeloid cell-mediated inflammation8
    Hypoxia-induced myocardial preconditioning4
    Hypoxia-induced cell cycle arrest17