Table 1.

Mouse claudin knockouts and transgenics

GenePhenotypeReference
KO, knockout; TG, transgenic; BBB, blood-brain barrier; CNS, central nervous system.
cln-1 KOSkin barrier defect 20
cln-5 KOSize-selective BBB defect 41
cln-6 TG Skin barrier defect 62
cln-11 KOCNS myelin defect 23
cln-14 KOPhenocopy of human 7